Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC5797184 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zheng Yiyan Y Sethi Ritika R Mangala Lingegowda S LS Taylor Charlotte C Goldsmith Juliet J Wang Ming M Masuda Kenta K Carrami Eli M EM Mannion David D Miranda Fabrizio F Herrero-Gonzalez Sandra S Hellner Karin K Chen Fiona F Alsaadi Abdulkhaliq A Albukhari Ashwag A Fotso Donatien Chedom DC Yau Christopher C Jiang Dahai D Pradeep Sunila S Rodriguez-Aguayo Cristian C Lopez-Berestein Gabriel G Knapp Stefan S Gray Nathanael S NS Campo Leticia L Myers Kevin A KA Dhar Sunanda S Ferguson David D Bast Robert C RC Sood Anil K AK von Delft Frank F Ahmed Ahmed Ashour AA
Nature communications 20180202 1
Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitaxel response has not been tested. Here, we show a previously unrecognized role of the microtubule-associated protein CRMP2 in inducing microtubule bundling through its carboxy terminus. This activity i ...[more]