Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians.
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ABSTRACT:
SUBMITTER: Zeng Q
PROVIDER: S-EPMC5797414 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians.
Zeng Qian Q Chen Xiaoping X Ning Chaoxue C Zhu Qiao Q Yao Yao Y Zhao Yali Y Luan Fuxin F
BMC medical genomics 20180202 1
<h4>Background</h4>Human aging is a hot topic in biology, and it has been associated with DNA methylation changes at specific genomic sites. We aimed to study the changes of DNA methylation at a single-CpG-site resolution using peripheral blood samples from centenarians.<h4>Methods</h4>Using Illumina 450 K Methylation BeadChip microarray assays, we carried out a pool-based, epigenome-wide investigation of DNA methylation of blood samples from 12 centenarians and 12 healthy controls. Differential ...[more]
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