Ontology highlight
ABSTRACT:
SUBMITTER: Roberts DW
PROVIDER: S-EPMC5797501 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Roberts David W DW Olson Jonathan D JD Evans Linton T LT Kolste Kolbein K KK Kanick Stephen C SC Fan Xiaoyao X Bravo Jaime J JJ Wilson Brian C BC Leblond Frederic F Marois Mikael M Paulsen Keith D KD
Journal of neurosurgery 20170804 6
OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination. METHODS To overcome the shallow tissue penetration of blue light, which maximally excites the ALA-induced fluorophore protoporphyrin IX (PpIX) but is also strongly absorbed by hemoglobin and oxyhemoglobin, a system was developed to illuminate the surgical field with red light (620-640 nm) matching a seconda ...[more]