Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC5797583 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Li Defang D Lu Ning N Han Jichun J Chen Xiaoyu X Hao Wenjin W Xu Wenjuan W Liu Xiaona X Ye Lei L Zheng Qiusheng Q
Frontiers in pharmacology 20180130
Myocardial ischemia-reperfusion (I/R) injury remains the leading risk factor of disability and mortality worldwide. In this study, the myocardial protective effect of eriodictyol (EDT) and the underlying mechanism in an <i>ex vivo</i> model of global myocardial I/R was investigated. After treatment with different concentrations of EDT, the decreased hemodynamic parameters induced by myocardial I/R injury were significantly attenuated by EDT. The elevated levels of IL-6, CRP, IL-8, and TNF-α were ...[more]