Ontology highlight
ABSTRACT:
SUBMITTER: Rubiano A
PROVIDER: S-EPMC5797706 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Rubiano Andres A Delitto Daniel D Han Song S Gerber Michael M Galitz Carly C Trevino Jose J Thomas Ryan M RM Hughes Steven J SJ Simmons Chelsey S CS
Acta biomaterialia 20171202
Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal, in large part due to a protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is thought to promote cancer cell survival and confounds attempts to develop effective therapies. We present a 3D in vitro system that replicates the mechanical properties of the PDAC microenvironment, representing an invaluable tool for understanding the biology of the disease. Mesoscale indentation quantified vis ...[more]