Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease.
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ABSTRACT:
SUBMITTER: Hippen KL
PROVIDER: S-EPMC5797736 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease.
Hippen Keli L KL Loschi Michael M Nicholls Jemma J MacDonald Kelli P A KPA Blazar Bruce R BR
Frontiers in immunology 20180131
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically s ...[more]
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2021-05-11 | GSE174214 | GEO