Ontology highlight
ABSTRACT:
SUBMITTER: Bezie S
PROVIDER: S-EPMC5797797 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Bézie Séverine S Meistermann Dimitri D Boucault Laetitia L Kilens Stéphanie S Zoppi Johanna J Autrusseau Elodie E Donnart Audrey A Nerrière-Daguin Véronique V Bellier-Waast Frédérique F Charpentier Eric E Duteille Franck F David Laurent L Anegon Ignacio I Guillonneau Carole C
Frontiers in immunology 20180131
Both CD4<sup>+</sup> and CD8<sup>+</sup> Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8<sup>+</sup> Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8<sup>+</sup>CD45RC<sup>low/-</sup> Tregs expressing Foxp3 and producing IFNγ, IL-10, IL-34, and TGFβ to mediate their suppressive activity. We demonstrate that total CD8<sup>+</sup>CD45RC<s ...[more]