Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC5797944 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Lee Jinhwa J Henningson Jamie J Ma Jingjiao J Duff Michael M Lang Yuekun Y Li Yonghai Y Li Yuhao Y Nagy Abdou A Sunwoo Sunyoung S Bawa Bhupinder B Yang Jianmei J Bai Dingping D Richt Juergen A JA Ma Wenjun W
The Journal of general virology 20170101 1
Although several studies have exploited the effects of PB1-F2 in swine influenza viruses, its contribution to the pathogenicity of swine influenza viruses remains unclear. Herein, we investigated the effects of PB1-F2 on the pathogenicity of influenza virus using a virulent H1N1 A/swine/Kansas/77778/2007 (KS07) virus, which expresses a full-length PB1-F2, in mice and pigs. Using reverse genetics, we generated the wild-type KS07 (KS07_WT), a PB1-F2 knockout mutant (KS07_K/O) and its N66S variant ...[more]