Ontology highlight
ABSTRACT:
SUBMITTER: Smith BM
PROVIDER: S-EPMC5798356 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Smith Benjamin M BM Traboulsi Hussein H Austin John H M JHM Manichaikul Ani A Hoffman Eric A EA Bleecker Eugene R ER Cardoso Wellington V WV Cooper Christopher C Couper David J DJ Dashnaw Stephen M SM Guo Jia J Han MeiLan K MK Hansel Nadia N NN Hughes Emlyn W EW Jacobs David R DR Kanner Richard E RE Kaufman Joel D JD Kleerup Eric E Lin Ching-Long CL Liu Kiang K Lo Cascio Christian M CM Martinez Fernando J FJ Nguyen Jennifer N JN Prince Martin R MR Rennard Stephen S Rich Stephen S SS Simon Leora L Sun Yanping Y Watson Karol E KE Woodruff Prescott G PG Baglole Carolyn J CJ Barr R Graham RG
Proceedings of the National Academy of Sciences of the United States of America 20180116 5
Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and exhibit strong familial aggregation. The most common airway branch variant is associated with COPD in two cohorts (<i>n</i> = 5,054), with great ...[more]