Ontology highlight
ABSTRACT:
SUBMITTER: Toti KS
PROVIDER: S-EPMC5798474 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Toti Kiran S KS Jain Shanu S Ciancetta Antonella A Balasubramanian Ramachandran R Chakraborty Saibal S Surujdin Ryan R Shi Zhen-Dan ZD Jacobson Kenneth A KA
MedChemComm 20170906 10
Both agonists and antagonists of the UDP-activated P2Y<sub>6</sub> receptor (P2Y<sub>6</sub>R) have been proposed for therapeutic use, in conditions such as cancer, inflammation, neurodegeneration and diabetes. Uracil nucleotides containing a South-bicyclo[3.1.0]hexane ((S)-methanocarba) ring system in place of the ribose ring were synthesized and shown to be potent P2Y<sub>6</sub>R agonists in a calcium mobilization assay. The (S)-methanocarba modification was compatible with either a 5-iodo or ...[more]