Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.
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ABSTRACT:
SUBMITTER: Chavali PL
PROVIDER: S-EPMC5798584 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.
Chavali Pavithra L PL Stojic Lovorka L Meredith Luke W LW Joseph Nimesh N Nahorski Michael S MS Sanford Thomas J TJ Sweeney Trevor R TR Krishna Ben A BA Hosmillo Myra M Firth Andrew E AE Bayliss Richard R Marcelis Carlo L CL Lindsay Susan S Goodfellow Ian I Woods C Geoffrey CG Gergely Fanni F
Science (New York, N.Y.) 20170601 6346
A recent outbreak of Zika virus in Brazil has led to a simultaneous increase in reports of neonatal microcephaly. Zika targets cerebral neural precursors, a cell population essential for cortical development, but the cause of this neurotropism remains obscure. Here we report that the neural RNA-binding protein Musashi-1 (MSI1) interacts with the Zika genome and enables viral replication. Zika infection disrupts the binding of MSI1 to its endogenous targets, thereby deregulating expression of fac ...[more]
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