Genome-wide association study of treatment response to venlafaxine XR in generalized anxiety disorder.
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SUBMITTER: Jung J
PROVIDER: S-EPMC5798606 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Genome-wide association study of treatment response to venlafaxine XR in generalized anxiety disorder.
Jung Jeesun J Tawa Elisabeth A EA Muench Christine C Rosen Allison D AD Rickels Karl K Lohoff Falk W FW
Psychiatry research 20170414
We conducted the first genome-wide association study (GWAS) in Generalized Anxiety Disorder (GAD) to identify potential predictors of venlafaxine XR treatment outcome. Ninety-eight European American patients participated in a venlafaxine XR clinical trial for GAD, with Hamilton Anxiety Scale (HAM-A) response/remission at 24 weeks as the primary outcome measure. All participants were genotyped with the Illumina PsychChip, and 266,820 common single nucleotide polymorphisms (SNPs) were analyzed. Al ...[more]
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