Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease.

ABSTRACT: OBJECTIVE:Inflammatory response plays an important role in Parkinson disease (PD). Previous studies have reported an association between human leukocyte antigen (HLA)-DRB1 and the risk of PD. There has also been growing interest in investigating whether inflammation-related genes interact with environmental factors such as smoking to influence PD risk. We performed a pooled analysis of the interaction between HLA-DRB1 and smoking in PD in 3 population-based case-control studies from Denmark and France. METHODS:We included 2,056 cases and 2,723 controls from 3 PD studies (Denmark, France) that obtained information on smoking through interviews. Genotyping of the rs660895 polymorphism in the HLA-DRB1 region was based on saliva or blood DNA samples. To assess interactions, we used logistic regression with product terms between rs660895 and smoking. We performed random-effects meta-analysis of marginal associations and interactions. RESULTS:Both carrying rs660895-G (AG vs AA: odds ratio [OR]?=?0.81; GG vs AA: OR?=?0.56; p-trend?=?0.003) and ever smoking (OR?=?0.56, p?

SUBMITTER: Chuang YH 

PROVIDER: S-EPMC5798887 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature