Ontology highlight
ABSTRACT:
SUBMITTER: Rouleau SG
PROVIDER: S-EPMC5798953 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Rouleau Samuel G SG Garant Jean-Michel JM Bolduc François F Bisaillon Martin M Perreault Jean-Pierre JP
RNA biology 20171211 2
RNA G-Quadruplexes (G4) have been shown to possess many biological functions, including the regulation of microRNA (miRNA) biogenesis and function. However, their impact on pri-miRNA processing remains unknown. We identified G4 located near the Drosha cleavage site in three distinct pri-miRNAs: pri-mir200c, pri-mir451a, and pri-mir497. The folding of the potential G4 motifs was determined in solution. Subsequently, mutations disrupting G4 folding led to important changes in the mature miRNAs lev ...[more]