Ontology highlight
ABSTRACT:
SUBMITTER: Herring CA
PROVIDER: S-EPMC5799016 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Herring Charles A CA Banerjee Amrita A McKinley Eliot T ET Simmons Alan J AJ Ping Jie J Roland Joseph T JT Franklin Jeffrey L JL Liu Qi Q Gerdes Michael J MJ Coffey Robert J RJ Lau Ken S KS
Cell systems 20171115 1
Modern single-cell technologies allow multiplexed sampling of cellular states within a tissue. However, computational tools that can infer developmental cell-state transitions reproducibly from such single-cell data are lacking. Here, we introduce p-Creode, an unsupervised algorithm that produces multi-branching graphs from single-cell data, compares graphs with differing topologies, and infers a statistically robust hierarchy of cell-state transitions that define developmental trajectories. We ...[more]