Ontology highlight
ABSTRACT:
SUBMITTER: Rusecka J
PROVIDER: S-EPMC5799321 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Rusecka Joanna J Kaliszewska Magdalena M Bartnik Ewa E Tońska Katarzyna K
Journal of applied genetics 20180117 1
Mitochondrial diseases are defined by a respiratory chain dysfunction and in most of the cases manifest as multisystem disorders with predominant expression in muscles and nerves and may be caused by mutations in mitochondrial (mtDNA) or nuclear (nDNA) genomes. Most of the proteins involved in respiratory chain function are nuclear encoded, although 13 subunits of respiratory chain complexes (together with 2 rRNAs and 22 tRNAs necessary for their translation) encoded by mtDNA are essential for c ...[more]