Ontology highlight
ABSTRACT:
SUBMITTER: Perego M
PROVIDER: S-EPMC5799768 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Perego M M Maurer M M Wang J X JX Shaffer S S Müller A C AC Parapatics K K Li L L Hristova D D Shin S S Keeney F F Liu S S Xu X X Raj A A Jensen J K JK Bennett K L KL Wagner S N SN Somasundaram R R Herlyn M M
Oncogene 20170918 3
Melanoma is a heterogeneous tumor with different subpopulations showing different proliferation rates. Slow-cycling cells were previously identified in melanoma, but not fully biologically characterized. Using the label-retention method, we identified a subpopulation of slow-cycling cells, defined as label-retaining cells (LRC), with strong invasive properties. We demonstrate through live imaging that LRC are leaving the primary tumor mass at a very early stage and disseminate to peripheral orga ...[more]