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Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure.


ABSTRACT: Few birth cohort studies have examined the role of traffic-related air pollution (TRAP) in the development of infantile atopic dermatitis (AD), but none have investigated the role of preventive factors such as green spaces. The aim of this study was to investigate whether exposure to nitrogen dioxide (NO?) and particulate matter with an aerodynamic diameter of <10 ?m (PM10) during pregnancy is associated with increased risk of development of AD in 6-month-old children and also to examine how this association changes with residential green space. This study used prospective data from 659 participants of the Mothers and Children's Environmental Health study. Subjects were geocoded to their residential addresses and matched with air pollution data modeled using land-use regression. Information on infantile AD was obtained by using a questionnaire administered to the parents or guardians of the children. The association between infantile AD and exposure to NO? and PM10 was determined using logistic regression models. We assessed the effects of residential green spaces using stratified analyses and by entering product terms into the logistic regression models. The risk of infantile AD significantly increased with an increase in air pollution exposure during the first trimester of pregnancy. The adjusted odds ratio (OR) and 95% confidence interval (CI) were 1.219 (1.023-1.452) per 10 ?g/m³ increase in PM10 and 1.353 (1.027-1.782) per 10 ppb increase in NO?. An increase in the green space within 200 m of residence was associated with a decreased risk of AD (OR = 0.996, 95% CI: 0.993-0.999). The stratified analysis of residential green space revealed stronger associations between infantile AD and PM10 and NO? exposure during the first trimester in the areas in the lower tertiles of green space. This study indicated that exposure to TRAP during the first trimester of pregnancy is associated with infantile AD. Less residential green space may intensify the association between TRAP exposure and infantile AD.

SUBMITTER: Lee JY 

PROVIDER: S-EPMC5800201 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure.

Lee Ji-Young JY   Lamichhane Dirga Kumar DK   Lee Myeongjee M   Ye Shinhee S   Kwon Jung-Hyun JH   Park Myung-Sook MS   Kim Hwan-Cheol HC   Leem Jong-Han JH   Hong Yun-Chul YC   Kim Yangho Y   Ha Mina M   Ha Eunhee E  

International journal of environmental research and public health 20180109 1


Few birth cohort studies have examined the role of traffic-related air pollution (TRAP) in the development of infantile atopic dermatitis (AD), but none have investigated the role of preventive factors such as green spaces. The aim of this study was to investigate whether exposure to nitrogen dioxide (NO₂) and particulate matter with an aerodynamic diameter of <10 μm (PM<sub>10</sub>) during pregnancy is associated with increased risk of development of AD in 6-month-old children and also to exam  ...[more]

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