Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle.
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ABSTRACT:
SUBMITTER: Dasgupta A
PROVIDER: S-EPMC5800858 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle.
Dasgupta Agnik A Merkel Matthias M Clark Madeline J MJ Jacob Andrew E AE Dawson Jonathan Edward JE Manning M Lisa ML Amack Jeffrey D JD
eLife 20180129
How epithelial cell behaviors are coordinately regulated to sculpt tissue architecture is a fundamental question in biology. Kupffer's vesicle (KV), a transient organ with a fluid-filled lumen, provides a simple system to investigate the interplay between intrinsic cellular mechanisms and external forces during epithelial morphogenesis. Using 3-dimensional (3D) analyses of single cells we identify asymmetric cell volume changes along the anteroposterior axis of KV that coincide with asymmetric c ...[more]
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