¹⁸F-Sodium Fluoride Uptake in Abdominal Aortic Aneurysms: The SoFIA³ Study.

ABSTRACT:

Background

Fluorine-18-sodium fluoride (¹⁸F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque.

Objectives

In patients with abdominal aortic aneurysm (AAA), the authors assessed whether ¹⁸F-NaF positron emission tomography (PET) and computed tomography (CT) predicts AAA growth and clinical outcomes.

Methods

In prospective case-control (n = 20 per group) and longitudinal cohort (n = 72) studies, patients with AAA (aortic diameter >40 mm) and control subjects (aortic diameter <30 mm) underwent abdominal ultrasound, ¹⁸F-NaF PET-CT, CT angiography, and calcium scoring. Clinical endpoints were aneurysm expansion and the composite of AAA repair or rupture.

Results

Fluorine-18-NaF

SUBMITTER: Forsythe RO 

PROVIDER: S-EPMC5800891 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature