Ontology highlight
ABSTRACT:
SUBMITTER: Denisov IG
PROVIDER: S-EPMC5800941 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Biochemistry 20171214 5
Heterotropic interactions between atorvastatin (ARVS) and dronedarone (DND) have been deciphered using global analysis of the results of binding and turnover experiments for pure drugs and their mixtures. The in vivo presence of atorvastatin lactone (ARVL) was explicitly taken into account by using pure ARVL in analogous experiments. Both ARVL and ARVS inhibit DND binding and metabolism, while a significantly higher affinity of CYP3A4 for ARVL makes the latter the main modulator of activity (eff ...[more]