Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5800963 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chen Xi X Weber Craig C Farrell Emily T ET Alvarado Francisco J FJ Zhao Yan-Ting YT Gómez Ana M AM Valdivia Héctor H HH
Journal of molecular and cellular cardiology 20171122
Sorcin, a penta-EF hand Ca<sup>2+</sup>-binding protein expressed in cardiomyocytes, is known to interact with ryanodine receptors and other Ca<sup>2+</sup> regulatory proteins. To investigate sorcin's influence on cardiac excitation-contraction coupling and its role in the development of cardiac malfunctions, we generated a sorcin knockout (KO) mouse model. Sorcin KO mice presented ventricular arrhythmia and sudden death when challenged by acute stress induced by isoproterenol plus caffeine. Ch ...[more]