Ontology highlight
ABSTRACT:
SUBMITTER: Martinovich KM
PROVIDER: S-EPMC5801198 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Martinovich Kelly M KM Shaw Nicole C NC Kicic Anthony A Schultz André A Fletcher Sue S Wilton Steve D SD Stick Stephen M SM
Molecular and cellular pediatrics 20180206 1
Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design. Through targeting th ...[more]