Ontology highlight
ABSTRACT:
SUBMITTER: Ning F
PROVIDER: S-EPMC5801358 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
American journal of translational research 20180115 1
The Polycomb Repressive Complex 2 (PRC2) component PHD Finger Protein 19 (<i>phf19</i>) gene has been identified to be associated with rheumatoid arthritis (RA) risk. Here we show that Phf19 is highly expressed in murine germinal centers (GCs) and RA patients. To investigate the function of Phf19 in lymphocytes, we generated RAG1-deficient mice reconstituted with Phf19 or control-vector transduced bone marrow (BM) cells. Lymphogenesis in primary lymphoid tissues of Phf19-RM is normal, however, P ...[more]