Epidemiology of Pediatric Multidrug-Resistant Tuberculosis in the United States, 1993-2014.

ABSTRACT:

Background

Multidrug-resistant tuberculosis (MDR-TB) is an important global public health threat, but accurate estimates of MDR-TB burden among children are lacking.

Methods

We analyzed demographic, clinical, and laboratory data for newly diagnosed pediatric (age <15 years) TB cases reported to the US National TB Surveillance System during 1993-2014. MDR-TB was defined as culture-confirmed TB disease with resistance to at least isoniazid and rifampicin. To ascertain potential underestimation of pediatric MDR-TB, we surveyed high-burden states for clinically diagnosed cases treated for MDR-TB.

Results

Of 20789 pediatric TB cases, 5162 (24.8%) had bacteriologically confirmed TB. Among 4826 (93.5%) with drug susceptibility testing, 82 (1.7%) had MDR-TB. Most pediatric MD

SUBMITTER: Smith SE 

PROVIDER: S-EPMC5801661 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature