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Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

ABSTRACT: Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment.Data from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells.By bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer.ETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients.

SUBMITTER: Vasaikar S

PROVIDER: S-EPMC5801893 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

Vasaikar Suhas S Tsipras Giorgos G Landázuri Natalia N Costa Helena H Wilhelmi Vanessa V Scicluna Patrick P Cui Huanhuan L HL Mohammad Abdul-Aleem AA Davoudi Belghis B Shang Mingmei M Ananthaseshan Sharan S Strååt Klas K Stragliotto Giuseppe G Rahbar Afsar A Wong Kum Thong KT Tegner Jesper J Yaiw Koon-Chu KC Söderberg-Naucler Cecilia C

BMC cancer 20180206 1

<h4>Background</h4>Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatm ...[more]

PMID: 29409474

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Dataset Information

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

Publications

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

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