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Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors.


ABSTRACT: Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive processes on perception and may represent an objective means to discern people with a need for treatment from those without.

SUBMITTER: Powers AR 

PROVIDER: S-EPMC5802347 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors.

Powers A R AR   Mathys C C   Corlett P R PR  

Science (New York, N.Y.) 20170801 6351


Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and tr  ...[more]

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