Ontology highlight
ABSTRACT:
SUBMITTER: Akinduro O
PROVIDER: S-EPMC5802720 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Akinduro O O Weber T S TS Ang H H Haltalli M L R MLR Ruivo N N Duarte D D Rashidi N M NM Hawkins E D ED Duffy K R KR Lo Celso C C
Nature communications 20180206 1
Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the proliferation dynamics of primitive haematopoietic compartments and acute myeloid leukaemia (AML). We observe an unchanging proportion of AML cells entering S phase per hour throughout disease progression, with substantial BM egress at high levels of ...[more]