Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Sagaseta J
PROVIDER: S-EPMC5802752 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
López-Sagaseta Jacinto J Beernink Peter T PT Bianchi Federica F Santini Laura L Frigimelica Elisabetta E Lucas Alexander H AH Pizza Mariagrazia M Bottomley Matthew J MJ
Nature communications 20180206 1
Data obtained recently in the United Kingdom following a nationwide infant immunization program against serogroup B Neisseria meningitidis (MenB) reported >80% 4CMenB vaccine-mediated protection. Factor H-binding protein (fHbp) is a meningococcal virulence factor and a component of two new MenB vaccines. Here, we investigated the structural bases underlying the fHbp-dependent protective antibody response in humans, which might inform future antigen design efforts. We present the co-crystal struc ...[more]