Closed-loop stimulation of temporal cortex rescues functional networks and improves memory.
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ABSTRACT:
SUBMITTER: Ezzyat Y
PROVIDER: S-EPMC5802791 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Closed-loop stimulation of temporal cortex rescues functional networks and improves memory.
Ezzyat Youssef Y Wanda Paul A PA Levy Deborah F DF Kadel Allison A Aka Ada A Pedisich Isaac I Sperling Michael R MR Sharan Ashwini D AD Lega Bradley C BC Burks Alexis A Gross Robert E RE Inman Cory S CS Jobst Barbara C BC Gorenstein Mark A MA Davis Kathryn A KA Worrell Gregory A GA Kucewicz Michal T MT Stein Joel M JM Gorniak Richard R Das Sandhitsu R SR Rizzuto Daniel S DS Kahana Michael J MJ
Nature communications 20180206 1
Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to later ...[more]
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