Prospective evaluation of EUS-guided fine needle biopsy in pancreatic mass lesions.

ABSTRACT: Background and study aim?:Due to the scarcity of specific data on endoscopic ultrasound (EUS)-guided fine-needle biopsies (SharkCore) FNB in the evaluation of pancreatic lesions, we performed a prospective study of the diagnostic performance of EUS SharkCore FNB in patients with pancreatic lesions. The aim of this study was to evaluate the diagnostic accuracy. Patients and methods?:Single-center prospective study of 41 consecutive patients referred for EUS-FNB from October 2015 to April 2016 at our center. EUS-FNB was obtained in a predefined setting regarding the procedure and pathological evaluation. Data regarding demographics, lesion, technical parameters, and diagnostic accuracy were obtained. Results?:The study included 41 consecutive patients (22 males (54?%); median age 68 years). The average size of the lesions was 28?mm (median: 30?mm). A diagnostic specimen was identified in 40 (98?%) cases during microscopy with an average of 2.4 passes. The route was trans-duodenal in 20 cases (49?%). The histological diagnosis of the specimens was malignant in 29 cases (71?%), benign in 8 (20?%), suspicious in 2 (5?%), atypical in 1 (2?%) and in 1 (2?%) no material for microscopic evaluation was obtained. This led to a diagnostic accuracy of 93?%, sensitivity of 91?% and a specificity of 100?%. 2 cases (5?%) of self-limiting bleeding were observed. The diagnosis at follow up was malignant in 32 (78?%) of the patients. Conclusions?:EUS-FNB of pancreatic mass lesions with the SharkCore needle produced specimens with a diagnostic accuracy of 93?%. The procedure was safe and easy to perform, and these data support the use of EUS-FNB in a routine setting.

SUBMITTER: Larsen MH 

PROVIDER: S-EPMC5803003 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature