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Pyrazines from bacteria and ants: convergent chemistry within an ecological niche.


ABSTRACT: Ants use pheromones to coordinate their communal activity. Volatile pyrazines, for instance, mediate food resource gathering and alarm behaviors in different ant species. Here we report that leaf-cutter ant-associated bacteria produce a family of pyrazines that includes members previously identified as ant trail and alarm pheromones. We found that L-threonine induces the bacterial production of the trail pheromone pyrazines, which are common for the host leaf-cutter ants. Isotope feeding experiments revealed that L-threonine along with sodium acetate were the biosynthetic precursors of these natural products and a biosynthetic pathway was proposed.

SUBMITTER: Silva-Junior EA 

PROVIDER: S-EPMC5803209 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Pyrazines from bacteria and ants: convergent chemistry within an ecological niche.

Silva-Junior Eduardo A EA   Ruzzini Antonio C AC   Paludo Camila R CR   Nascimento Fabio S FS   Currie Cameron R CR   Clardy Jon J   Pupo Mônica T MT  

Scientific reports 20180207 1


Ants use pheromones to coordinate their communal activity. Volatile pyrazines, for instance, mediate food resource gathering and alarm behaviors in different ant species. Here we report that leaf-cutter ant-associated bacteria produce a family of pyrazines that includes members previously identified as ant trail and alarm pheromones. We found that L-threonine induces the bacterial production of the trail pheromone pyrazines, which are common for the host leaf-cutter ants. Isotope feeding experim  ...[more]

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