PilVax - a novel peptide delivery platform for the development of mucosal vaccines.

ABSTRACT: Peptide vaccines are an attractive strategy to engineer the induction of highly targeted immune responses and avoid potentially allergenic and/or reactogenic protein regions. However, peptides by themselves are often unstable and poorly immunogenic, necessitating the need for an adjuvant and a specialised delivery system. We have developed a novel peptide delivery platform (PilVax) that allows the presentation of a stabilised and highly amplified peptide as part of the group A streptococcus serotype M1 pilus structure (PilM1) on the surface of the non-pathogenic bacterium Lactococcus lactis. To show proof of concept, we have successfully inserted the model peptide Ova_324-339 into 3 different loop regions of the backbone protein Spy0128, which resulted in the assembly of the pilu

SUBMITTER: Wagachchi D 

PROVIDER: S-EPMC5803258 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature