Ontology highlight
ABSTRACT:
SUBMITTER: Gong Y
PROVIDER: S-EPMC5803259 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180207 1
The metazoan genome is compartmentalized in areas of highly interacting chromatin known as topologically associating domains (TADs). TADs are demarcated by boundaries mostly conserved across cell types and even across species. However, a genome-wide characterization of TAD boundary strength in mammals is still lacking. In this study, we first use fused two-dimensional lasso as a machine learning method to improve Hi-C contact matrix reproducibility, and, subsequently, we categorize TAD boundarie ...[more]