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Stereochemical Sequence Dictates Unimolecular Diblock Copolymer Assembly.

ABSTRACT: Deciphering the significance of length, sequence, and stereochemistry in block copolymer self-assembly remains an ongoing challenge. A dearth of methods to access uniform block co-oligomers/polymers with precise stereochemical sequences has precluded such studies. Here, we develop iterative exponential growth methods for the synthesis of a small library of unimolecular stereoisomeric diblock 32-mers. X-ray scattering reveals that stereochemistry modulates the phase behavior of these polymers, which we rationalize based on simulations carried out on a theoretical model system. This work demonstrates that stereochemical sequence can play a crucial role in unimolecular polymer self-assembly.

SUBMITTER: Golder MR

PROVIDER: S-EPMC5803323 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Stereochemical Sequence Dictates Unimolecular Diblock Copolymer Assembly.

Golder Matthew R MR Jiang Yivan Y Teichen Paul E PE Nguyen Hung V-T HV Wang Wencong W Milos Nicole N Freedman Seth A SA Willard Adam P AP Johnson Jeremiah A JA

Journal of the American Chemical Society 20180122 5

Deciphering the significance of length, sequence, and stereochemistry in block copolymer self-assembly remains an ongoing challenge. A dearth of methods to access uniform block co-oligomers/polymers with precise stereochemical sequences has precluded such studies. Here, we develop iterative exponential growth methods for the synthesis of a small library of unimolecular stereoisomeric diblock 32-mers. X-ray scattering reveals that stereochemistry modulates the phase behavior of these polymers, wh ...[more]

PMID: 29356516

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