Ontology highlight
ABSTRACT:
SUBMITTER: Schulte ML
PROVIDER: S-EPMC5803339 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Schulte Michael L ML Fu Allie A Zhao Ping P Li Jun J Geng Ling L Smith Shannon T ST Kondo Jumpei J Coffey Robert J RJ Johnson Marc O MO Rathmell Jeffrey C JC Sharick Joe T JT Skala Melissa C MC Smith Jarrod A JA Berlin Jordan J Washington M Kay MK Nickels Michael L ML Manning H Charles HC
Nature medicine 20180115 2
The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer metabolism has led to surprisingly few new drugs to date. The neutral amino acid glutamine serves as a key intermediate in numerous metabolic processes leveraged by cancer cells, including biosynthesis, cell signaling, and oxidative protection. Herein we report the preclinical development of V-9302, a competitive ...[more]