Low-temperature magnetic resonance imaging with 2.8??m isotropic resolution.

ABSTRACT: We demonstrate the feasibility of high-resolution 1H magnetic resonance imaging (MRI) at low temperatures by obtaining an MRI image of 20??m diameter glass beads in glycerol/water at 28?K with 2.8??m isotropic resolution. The experiments use a recently-described MRI apparatus (Moore and Tycko, 2015) with minor modifications. The sample is contained within a radio-frequency microcoil with 150??m inner diameter. Sensitivity is additionally enhanced by paramagnetic doping, optimization of the sample temperature, three-dimensional phase-encoding of k-space data, pulsed spin-lock detection of 1H nuclear magnetic resonance signals, and spherical sampling of k-space. We verify that the actual image resolution is 2.7?±?0.3??m by quantitative comparisons of experimental and calculated images. Our imaging approach is compatible with dynamic nuclear polarization, providing a path to significantly higher resolution in future experiments.

SUBMITTER: Chen HY 

PROVIDER: S-EPMC5803441 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature