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Low-temperature magnetic resonance imaging with 2.8??m isotropic resolution.

ABSTRACT: We demonstrate the feasibility of high-resolution 1H magnetic resonance imaging (MRI) at low temperatures by obtaining an MRI image of 20??m diameter glass beads in glycerol/water at 28?K with 2.8??m isotropic resolution. The experiments use a recently-described MRI apparatus (Moore and Tycko, 2015) with minor modifications. The sample is contained within a radio-frequency microcoil with 150??m inner diameter. Sensitivity is additionally enhanced by paramagnetic doping, optimization of the sample temperature, three-dimensional phase-encoding of k-space data, pulsed spin-lock detection of 1H nuclear magnetic resonance signals, and spherical sampling of k-space. We verify that the actual image resolution is 2.7?±?0.3??m by quantitative comparisons of experimental and calculated images. Our imaging approach is compatible with dynamic nuclear polarization, providing a path to significantly higher resolution in future experiments.

SUBMITTER: Chen HY

PROVIDER: S-EPMC5803441 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution.

Chen Hsueh-Ying HY Tycko Robert R

Journal of magnetic resonance (San Diego, Calif. : 1997) 20171220

We demonstrate the feasibility of high-resolution <sup>1</sup>H magnetic resonance imaging (MRI) at low temperatures by obtaining an MRI image of 20 μm diameter glass beads in glycerol/water at 28 K with 2.8 μm isotropic resolution. The experiments use a recently-described MRI apparatus (Moore and Tycko, 2015) with minor modifications. The sample is contained within a radio-frequency microcoil with 150 μm inner diameter. Sensitivity is additionally enhanced by paramagnetic doping, optimization o ...[more]

PMID: 29288890

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Low-temperature magnetic resonance imaging with 2.8??m isotropic resolution.

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Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution.

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Low-temperature magnetic resonance imaging with 2.8??m isotropic resolution.

Publications

Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution.

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OmicsDI is part of the ELIXIR infrastructure

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Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution.