Ontology highlight
ABSTRACT:
SUBMITTER: Vining KH
PROVIDER: S-EPMC5803560 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Vining Kyle H KH Mooney David J DJ
Nature reviews. Molecular cell biology 20171108 12
Stem cells and their local microenvironment, or niche, communicate through mechanical cues to regulate cell fate and cell behaviour and to guide developmental processes. During embryonic development, mechanical forces are involved in patterning and organogenesis. The physical environment of pluripotent stem cells regulates their self-renewal and differentiation. Mechanical and physical cues are also important in adult tissues, where adult stem cells require physical interactions with the extrace ...[more]