Dataset Information
Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.
Ontology highlight
ABSTRACT: Background
Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD).Methods
Male C57BL/6J mice were fed a HFD for 8 weeks to induce obesity and chronic inflammation. The mice were treated with a water extract of A. cinnamomea (WEAC), and body weight, fat accumulation, inflammation markers, insulin sensitivity and the gut microbiota were monitored.Results
After 8 weeks, the mean body weight of HFD-fed mice was 39.8±1.2?g compared with 35.8±1.3?g for the HFD+1% WEAC group, corresponding to a reduction of 4?g or 10% of body weight (P<0.0001). WEAC supplementation reduced fat accumulation and serum triglycerides in a statistically significant manner in HFD-fed mice. WEAC also reversed the effects of HFD on inflammation markers (interleukin-1?, interleukin-6, tumor necrosis factor-?), insulin resistance and adipokine production (leptin and adiponectin). Notably, WEAC increased the expression of intestinal tight junctions (zonula occludens-1 and occludin) and antimicrobial proteins (Reg3g and lysozyme C) in the small intestine, leading to reduced blood endotoxemia. Finally, WEAC modulated the composition of the gut microbiota, reducing the Firmicutes/Bacteroidetes ratio and increasing the level of Akkermansia muciniphila and other bacterial species associated with anti-inflammatory properties.Conclusions
Supplementation with A. cinnamomea produces anti-obesogenic, anti-inflammatory and antidiabetic effects in HFD-fed mice by maintaining intestinal integrity and modulating the gut microbiota.
SUBMITTER: Chang CJ
PROVIDER: S-EPMC5803574 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.
International journal of obesity (2005) 20170620 2
<h4>Background</h4>Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD).<h4>Methods</h4>Male C57BL/6J mice were fed a HFD for 8 weeks to induce obesity and chronic inflam ...[more]