A genetic locus for paranoia.
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ABSTRACT:
SUBMITTER: Crespi B
PROVIDER: S-EPMC5803597 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
A genetic locus for paranoia.
Crespi Bernard B Read Silven S Salminen Iiro I Hurd Peter P
Biology letters 20180101 1
The psychological effects of brain-expressed imprinted genes in humans are virtually unknown. Prader-Willi syndrome (PWS) is a neurogenetic condition mediated by genomic imprinting, which involves high rates of psychosis characterized by hallucinations and paranoia, as well as autism. Altered expression of two brain-expressed imprinted genes, <i>MAGEL2</i> and <i>NDN</i>, mediates a suite of PWS-related phenotypes, including behaviour, in mice. We phenotyped a large population of typical individ ...[more]
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