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The impact of disease severity on paradoxical association between body mass index and mortality in patients with acute kidney injury undergoing continuous renal replacement therapy.

ABSTRACT: Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those receiving continuous renal replacement therapy (CRRT), are highly catabolic and more susceptible to loss of energy. Herein, we evaluated whether disease severity can modify the relationship between BMI and mortality.We conducted an observational study in 1144 patients who had undergone CRRT owing to various causes of AKI between 2010 and 2014. Patients were categorized into four groups; underweight (

SUBMITTER: Kim H 

PROVIDER: S-EPMC5804063 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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The impact of disease severity on paradoxical association between body mass index and mortality in patients with acute kidney injury undergoing continuous renal replacement therapy.

Kim Hyoungnae H   Kim Hyunwook H   Lee Misol M   Cha Min-Uk MU   Nam Ki Heon KH   An Seong Yeong SY   Jung Su-Young SY   Jhee Jong Hyun JH   Park Seohyun S   Yun Hae-Ryong HR   Kee Youn Kyung YK   Oh Hyung Jung HJ   Park Jung Tak JT   Chang Tae Ik TI   Yoo Tae-Hyun TH   Kang Shin-Wook SW   Han Seung Hyeok SH  

BMC nephrology 20180207 1

<h4>Background</h4>Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those receiving continuous renal replacement therapy (CRRT), are highly catabolic and more susceptible to loss of energy. Herein, we evaluated whether disease severity can modify the relationship between BMI and mortality.<h4>Methods</h4>We conducted an observational study in  ...[more]

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