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Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea.


ABSTRACT: Background:Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects from medication resulting in physical, mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea. Methods:This is a retrospective cohort study that evaluated ADRs to antibiotics that were reported at a 2400-bed tertiary care hospital in 2015. ADRs reported by physicians, pharmacists, and nurses were reviewed. Clinical information reported ADRs, type of antibiotic, causality assessment, and complications were evaluated. Results:1,277 (62.8%) patients were considered antibiotic-related ADRs based on the World Health Organization-Uppsala Monitoring Center criteria (certain, 2.2%; probable, 35.7%; and possible, 62.1%). Totally, 44 (3.4%) patients experienced serious ADRs. Penicillin and quinolones were the most common drugs reported to induce ADRs (both 16.0%), followed by third-generation cephalosporins (14.9%). The most frequently experienced side effects were skin manifestations (45.1%) followed by gastrointestinal disorders (32.6%). Conclusion:Penicillin and quinolones are the most common causative antibiotics for ADRs and skin manifestations were the most frequently experienced symptom.

SUBMITTER: Jung IY 

PROVIDER: S-EPMC5804292 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea.

Jung In Young IY   Kim Jung Ju JJ   Lee Se Ju SJ   Kim Jinnam J   Seong Hye H   Jeong Wooyong W   Choi Heun H   Jeong Su Jin SJ   Ku Nam Su NS   Han Sang Hoon SH   Choi Jun Yong JY   Song Young Goo YG   Park Jung Won JW   Kim June Myung JM  

BioMed research international 20171231


<h4>Background</h4>Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects from medication resulting in physical, mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea.<h4>Methods</h4>This is a retrospective cohort study that evaluated ADRs to a  ...[more]

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