Dataset Information
High-Yielding Automated Convergent Synthesis of No-Carrier-Added [11C-Carbonyl]-Labeled Amino Acids Using the Strecker Reaction.
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ABSTRACT:
SUBMITTER: Xing J
PROVIDER: S-EPMC5804752 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
High-Yielding Automated Convergent Synthesis of No-Carrier-Added [<sup>11</sup>C-<i>Carbonyl</i>]-Labeled Amino Acids Using the Strecker Reaction.
Synlett : accounts and rapid communications in synthetic organic chemistry 20161107 3
A new variant of the Strecker synthesis using no-carrier-added [<sup>11</sup>C]cyanide for the synthesis of radiolabeled amino acids is described. The protocol is fully automated using a radiochemistry synthesis module and applied to the production of a number of new PET radiotracers. [<sup>11</sup>C-<i>Carbonyl</i>]sarcosine, [<sup>11</sup>C-<i>carbonyl</i>]methionine, [<sup>11</sup>C-<i>carbonyl</i>]-<i>N</i>-phenylglycine, and [<sup>11</sup>C-<i>carbonyl</i>]glycine are all synthesized in mod ...[more]