Ontology highlight
ABSTRACT:
SUBMITTER: Birey F
PROVIDER: S-EPMC5805137 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Birey Fikri F Andersen Jimena J Makinson Christopher D CD Islam Saiful S Wei Wu W Huber Nina N Fan H Christina HC Metzler Kimberly R Cordes KRC Panagiotakos Georgia G Thom Nicholas N O'Rourke Nancy A NA Steinmetz Lars M LM Bernstein Jonathan A JA Hallmayer Joachim J Huguenard John R JR Paşca Sergiu P SP
Nature 20170426 7652
The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral to dorsal forebrain and their integration into cortical circuits. However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids from human pluripotent stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GABAe ...[more]