Ontology highlight
ABSTRACT:
SUBMITTER: Mumbach MR
PROVIDER: S-EPMC5805393 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Mumbach Maxwell R MR Satpathy Ansuman T AT Boyle Evan A EA Dai Chao C Gowen Benjamin G BG Cho Seung Woo SW Nguyen Michelle L ML Rubin Adam J AJ Granja Jeffrey M JM Kazane Katelynn R KR Wei Yuning Y Nguyen Trieu T Greenside Peyton G PG Corces M Ryan MR Tycko Josh J Simeonov Dimitre R DR Suliman Nabeela N Li Rui R Xu Jin J Flynn Ryan A RA Kundaje Anshul A Khavari Paul A PA Marson Alexander A Corn Jacob E JE Quertermous Thomas T Greenleaf William J WJ Chang Howard Y HY
Nature genetics 20170925 11
The challenge of linking intergenic mutations to target genes has limited molecular understanding of human diseases. Here we show that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells. Differentiation of naive T cells into T helper 17 cells or regulatory T cells creates subtype-specific enhancer-promoter interactions, specifically at regions of shared DNA accessibility. These d ...[more]