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Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.

ABSTRACT: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drugs.

SUBMITTER: Manolio TA 

PROVIDER: S-EPMC5805563 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.

Manolio Teri A TA   Hutter Carolyn M CM   Avigan Mark M   Cibotti Ricardo R   Davis Robert L RL   Denny Joshua C JC   Grenade Lois La L   Wheatley Lisa M LM   Carrington Mary N MN   Chantratita Wasun W   Chung Wen-Hung WH   Dalton Andrea D AD   Hung Shuen-Iu SI   Lee Ming Ta Michael MTM   Leeder J Steven JS   Lertora Juan J L JJL   Mahasirimongkol Surakameth S   McLeod Howard L HL   Mockenhaupt Maja M   Pacanowski Michael M   Phillips Elizabeth J EJ   Pinheiro Simone S   Pirmohamed Munir M   Sung Cynthia C   Suwankesawong Wimon W   Trepanier Lauren L   Tumminia Santa J SJ   Veenstra David D   Yuliwulandari Rika R   Shear Neil H NH  

Clinical pharmacology and therapeutics 20171106 3

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is one of the most devastating of adverse drug reactions (ADRs) and was, until recently, essentially unpredictable. With the discovery of several risk alleles for drug-induced SJS/TEN and the demonstration of effectiveness of screening in reducing incidence, the stage is set for implementation of preventive strategies in populations at risk. Yet much remains to be learned about this potentially fatal complication of commonly used drug  ...[more]

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