Ontology highlight
ABSTRACT:
SUBMITTER: Belousov AB
PROVIDER: S-EPMC5805564 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Belousov Andrei B AB Nishimune Hiroshi H Denisova Janna V JV Fontes Joseph D JD
Neuroscience letters 20171212
Neuronal gap junctional protein connexin 36 (Cx36) contributes to neuronal death following a range of acute brain insults such as ischemia, traumatic brain injury and epilepsy. Whether Cx36 contributes to neuronal death and pathological outcomes in chronic neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), is not known. We show here that the expression of Cx36 is significantly decreased in lumbar segments of the spinal cord of both human ALS subjects and SOD1<sup>G93A</sup> ...[more]