Ontology highlight
ABSTRACT:
SUBMITTER: Poepsel S
PROVIDER: S-EPMC5805599 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20180129 2
Epigenetic regulation is mediated by protein complexes that couple recognition of chromatin marks to activity or recruitment of chromatin-modifying enzymes. Polycomb repressive complex 2 (PRC2), a gene silencer that methylates lysine 27 of histone H3, is stimulated upon recognition of its own catalytic product and has been shown to be more active on dinucleosomes than H3 tails or single nucleosomes. These properties probably facilitate local H3K27me2/3 spreading, causing heterochromatin formatio ...[more]