Ontology highlight
ABSTRACT:
SUBMITTER: Huang HC
PROVIDER: S-EPMC5805648 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Huang Huang-Chiao HC Liu Joyce J Baglo Yan Y Rizvi Imran I Anbil Sriram S Pigula Michael M Hasan Tayyaba T
Molecular cancer therapeutics 20171122 2
Mechanism-inspired drug repurposing that augments standard treatments offers a cost-effective and rapid route toward addressing the burgeoning problem of plateauing of effective therapeutics for drug-resistant micrometastases. We show that the antibiotic minocycline, by its ability to minimize DNA repair via reduced expression of tyrosyl-DNA phosphodiesterase-1 (Tdp1), removes a key process attenuating the efficacy of irinotecan, a frequently used chemotherapeutic against metastatic disease. Mor ...[more]