Ontology highlight
ABSTRACT:
SUBMITTER: Soncin I
PROVIDER: S-EPMC5805689 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180208 1
Circulating CCR2<sup>+</sup> monocytes are crucial for maintaining the adult tissue-resident F4/80<sup>hi</sup>MHCII<sup>hi</sup> macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80<sup>hi</sup>MHCII<sup>low</sup> macrophages, which are the most abundant F4/80<sup>hi</sup> cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80<sup>hi</sup> cells. In colon adenomas of ...[more]